High expectations will follow the Indianapolis Colts to Buffalo as they open the season away from home against the Bills and try to cover the spread for the fourth time in five games. The exception for the Colts during that stretch was a 45-7 road loss to the New England Patriots in the AFC Championship Game as 7-point road underdogs.
Indianapolis is the 3/1 favorite to win the AFC over the defending Super Bowl champion Patriots, and the opener could go a long way to showing how good this team can be this season.
With the addition of a pair of veteran offensive weapons in running back Frank Gore and wide receiver Andre Johnson, the Colts have given quarterback Andrew Luck exactly what he needs to get to the big game.
But Buffalo has one of the best defenses in the NFL, and new head coach Rex Ryan will be motivated to try to shut down Indy’s offense in his first game there, as the team goes for its sixth cover in seven games dating back to last year.
Opening Odds & Computer Pick
Odds makers at Bodog had the Buffalo Bills as 2.5-point underdogs in the game, while the betting total was sitting at 48.
Prediction-scoring formulas run on this game pick a potential 24-21 result in favor of the Colts. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.
Indianapolis Colts vs Buffalo Bills Matchup
Team Betting Records & Power Rankings
Buffalo battles the Indianapolis Colts, currently with a 13-6 mark (12-6-1 ATS). The over under records, important for totals betting, are 3-13 for the Bills and 9-10 for the Colts. Stay Informed: follow us on Twitter for odds specials, betting line moves and Buffalo vs Indianapolis injuries news.
The game pits the Buffalo Bills, currently No. 6 in our Odds – VSB
NFL Power Rankings, against the Indianapolis Colts, who rate No. 8 in the latest survey.
Offensively, the game matches up the Buffalo Bills No. 18-ranked offense (21.44 PPG) against a Indianapolis Colts defense that ranks No. 18 at 23 PPG. The Bills passing attack has averaged 225.88 yards per game, more than the Colts give up through the air (223 YPG on average).
Defensively, the Indianapolis Colts feature the league’s No. 21-rated road run defense, allowing 119.4 yards per game. The Buffalo Bills, meanwhile, ranks No. 19 in rushing offense at home.
Recent Outings Betting Recap
Indianapolis didn’t make much of a game of it last time out, losing to the Patriots as New England blasted them 45-7 in Conference Playoff action.
The Bills grabbed a Week 17 victory over the Patriots in their last game, winning 17-9 at Gillette Stadium.
- Indianapolis is 16-7-1 ATS in its last 24 games
- Indianapolis is 7-2 SU in its last 9 games
- The total has gone UNDER in 5 of Indianapolis’s last 5 games
- Indianapolis is 4-2 SU in its last 6 games on the road
- Buffalo is 5-1 ATS in its last 6 games
- Buffalo is 4-2 SU in its last 6 games
- The total has gone UNDER in 7 of Buffalo’s last 8 games
- Buffalo is 4-1 SU in its last 5 games at home
Next Betting Matchups
Indianapolis home to New York, Monday, September 21st
Buffalo home to New England, Sunday, September 20th