MNF Week 6: Rams vs 49ers Odds Pick


The San Francisco 49ers are just 1-3 ATS in their four most recent games against the division-rival St. Louis Rams as those NFC West clubs prepare to meet at the Edward Jones Dome on Monday Night Football.

San Francisco is also 7-1-1 ATS in its last nine games as a road favorite, but just 3-9 ATS in its last 12 road games against fellow NFC West teams. In contrast, the Rams are 5-2 ATS in their last seven home games vs. NFC West teams, with the OVER going 3-1 for totals bettors in the last four games between the Niners and the Rams in St. Louis.

San Francisco 49ers vs St. Louis Rams Opening Odds and Betting Line

The San Francisco 49ers were listed as -4-point favorites at sportsbooks such as TopBet, with the total listed at 43.5.

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Computer Prediction: San Francisco 49ers vs St. Louis Rams Pick

Odds – VSB
score prediction models pick a 25-18 result in favor of the 49ers on Monday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Francisco 49ers vs St. Louis Rams Odds and Stats.

Team Betting Records & Power Rankings

The St. Louis Rams sit at 1-3 (1-3 ATS) on the season; in comparison, the San Francisco 49ers are currently 3-2 (2-3 ATS). Looking to bet on the totals? St. Louis is 2-2 OU, and San Francisco is 1-4 OU. Stay Informed: follow us on Twitter for odds specials, betting line moves and St. Louis vs San Francisco injuries news.

The power rankings show a disparity between these teams, with the St. Louis Rams rated this week at No. 23 and the San Francisco 49ers sitting at No. 9.

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How San Francisco 49ers vs St. Louis Rams Stats Matchup

The game also pits St. Louis’s No. 22-ranked offense, averaging 21 PPG, against a 49ers defense that ranks No. 10 this week at 21.2 PPG. The Rams aerial game is averaging 283.5 yards per game, more than the 49ers secondary allows through the air, 209 YPG per game.

Defensively, the San Francisco 49ers feature the league’s No. 14-rated road run defense, allowing 105.5 yards per game. The St. Louis Rams, meanwhile, ranks No. 26 in rushing offense at home.

Recent Outings Betting Recap

Frank Gore went over the 100-yard mark (107) in his team’s latest effort as San Francisco defeated Kansas City by a score of 22-17 on Sunday.


Last time out, Austin Davis threw for 3 scores and 375 yards in a failed effort to defeat Philadelphia at Lincoln Financial Field.

San Francisco 49ers vs St. Louis Rams Betting Odds Trends

San Francisco is 2-4 ATS in its last 6 games
San Francisco is 11-3 SU in its last 14 games
The total has gone UNDER in 7 of San Francisco’s last 8 games
San Francisco is 8-2-2 ATS in its last 12 games on the road
St. Louis is 1-4 ATS in its last 5 games
St. Louis is 1-4 SU in its last 5 games
The total has gone UNDER in 7 of St. Louis’s last 9 games
The total has gone OVER in 10 of St. Louis’s last 15 games at home

Next Betting Matchups

San Francisco at Denver, Sunday, October 19th
St. Louis home to Seattle, Sunday, October 19th


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