NFL Opening Betting Lines: Week 5 Odds


Peyton Manning and the Denver Broncos have yet to cover a posted spread so far this season, and they’ll return from their bye in Week 5 as 7-point favorites on the opening NFL odds against the undefeated Arizona Cardinals.

Denver is 2-1 SU but 0-3 ATS on the season, failing to cover spreads in SU wins over Indianapolis and Kansas City and a SU loss against Seattle. The Broncos, however, are 4-1 ATS in their last five games against the Cardinals – who enter the matchup at 3-0 SU and 2-1 ATS on the season.

[ See the updated NFL Week 5 odds right now on the VSB NFL Odds page ]

Five other teams were favored by about a touchdown on the opening NFL betting lines for Week 5, with the Eagles at -7 against the Rams, the Lions at -6.5 against the Bills, the Niners at -7.5 against the Chiefs, the Chargers at -7 against the Jets, and the Seahawks at -7 against Washington on Monday Night Football.

The biggest favorites on the Week 5 opening NFL odds, however, were Green Bay -10 at home to Minnesota on Thursday Night Football, and New Orleans -12 at home to Tampa Bay. The Saints and Buccaneers have each started the season 1-3 both SU and ATS, and New Orleans is 4-1 ATS in its last five games against the Bucs. However, the Saints are coming off a 38-17 loss to Dallas, while Tampa Bay beat Pittsburgh 27-24 last week.

Matchup Reports: Cardinals vs. Broncos | Bucs vs. Saints | Steelers vs. Jaguars

The Steelers fell to 2-2 SU and 1-3 ATS with their last-minute loss to the Buccaneers last week, but they still opened as 5.5-point road favorites against the Jaguars in Jacksonville for Week 5. The Jags are 0-4 both SU and ATS on the season, but at least some of the NFL betting trends for the week are on their side – Jacksonville is 6-2 ATS in its last eight games against Pittsburgh.

Week 5 NFL Opening Betting Lines:

Minnesota at Green Bay (-10), 8:25pm ET

Chicago at Carolina (-2.5), 1:00pm ET
Cleveland at Tennessee (-2.5), 1:00pm ET
St. Louis at Philadelphia (-7), 1:00pm ET
Atlanta at NY Giants (-3.5), 1:00pm ET
Tampa Bay at New Orleans (-12), 1:00pm ET
Houston at Dallas (-4), 1:00pm ET
Buffalo at Detroit (-6.5), 1:00pm ET
Baltimore at Indianapolis (-3), 1:00pm ET
Pittsburgh at Jacksonville (+5.5), 1:00pm ET
Arizona at Denver (-7), 4:05pm ET
Kansas City at San Francisco (-7.5), 4:25pm ET
NY Jets at San Diego (-7), 4:25pm ET
Cincinnati at New England (-2.5), 8:30pm ET

Seattle at Washington (+7), 8:30pm ET


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